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US 9,428,506 B2Granted
Substituted pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines for the treatment of nervous system disorders
AssigneeIntra-Cellular Therapies, Inc.
InventorsSharon Mates, Robert Davis, Peng Li, Lawrence Wennogle, Kimberly Vanover
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Abstract
The invention relates to particular substituted heterocycle fused gamma-carbolines, of Formula I, in free, solid, pharmaceutically acceptable salt and/or substantially pure form as described herein, pharmaceutical compositions thereof, and methods of use in the treatment of diseases involving 5-HT2A receptor, serotonin transporter (SERT) and/or pathways involving dopamine D2 receptor signaling systems, such as disease of the central nervous system.
Claims30
A compound of formula I:
- wherein:
- X is N(H) or N(C1-4alkyl);
- R1 is H or C1-6alkyl;
- R2 is H or OR3, wherein R3 is H or C1-6 alkyl;
- provided that R1 and R2 are not both H, and R1 and R3 are not both H;
- in free base or pharmaceutically acceptable salt form.
3 more elements
Dependencies are inferred from the claim text.