Heterocyclic modulators of lipid synthesis

A compound having Structure II:

• or pharmaceutically acceptable salts thereof, wherein:
• L-Ar is
• Ar is
• with the proviso that when L-Ar is
• Ar is not
• Het is a 5- to 6-membered heteroaryl;
• R1 is H, —CN, halogen, C1-C4 alkyl, —O—(C3-C5 cycloalkyl), —O-(4- to 6-membered heterocycle) or —O—(C1-C4 alkyl), wherein when R1 is not H, —CN or halogen, R1 is optionally substituted with one or more halogens;
• each R2 is independently hydrogen, halogen or C1-C4 alkyl;
• R3 is H or F;
• R11 is H or —CH3;
• R21 is H, halogen, C1-C4 alkyl, C3-C5 cycloalkyl or 4- to 6-membered heterocycle;
• R22 is H, halogen, or C1-C2 alkyl;
• and
• R24 is H, C1-C4 alkyl, C1-C4 haloalkyl, —(C1-C4 alkyl)-OH, —(C1-C4 alkyl)t-N(R241)2, —(C1-C4 alkyl)t-Ot—(C3-C5 cycloalkyl), —(C1-C4 alkyl)t-Ot-(4- to 6-membered heterocycle) or —(C1-C4 alkyl)t-O—(C1-C4 alkyl), wherein:
• each t is independently 0 or 1;
• and
• each R241 is independently H or C1-C2 alkyl.