Back to results
US 9,428,501 B2Granted
Bicyclic nitrogen-containing aromatic heterocyclic amide compound
AssigneeAstellas Pharma Inc.
InventorsKei Ohnuki, Hidenori Azami, Yuki Sawada, Takashi Shin, Kazuyuki Kuramoto, Shigetoshi Kikuchi, Tomoyuki Saito, Hisao Hamaguchi, Takeyuki Nagashima
Life of this patent
Estimating the term…
Abstract
Compounds of formula (I) and salts thereof: wherein the variables are defined herein, are useful for the treatment of breast cancer.
Claims20
A compound of the formula (I) or a salt thereof:
- wherein R1 is aryl or monocyclic nitrogen-containing heteroaryl, each of which is optionally substituted with at least one substituent selected from the group consisting of halogen, lower alkyl, —O-lower alkyl, halogeno-lower alkyl, —O-halogeno-lower alkyl, —CN, dimethylamino, and cycloalkyl;
- wherein X is CH, N, or C;
- is a single bond if X is CH or N or is a double bond if X is C;
- Y is a cyclic group of any of formulae Y-1 to Y-11:
- Y1 is CRh or N;
- Y2 is CRi or N;
- Y1 and Y2 are not both N;
- Ra, Rb, and Ri are each independently H or halogen;
- Rb is H or lower alkyl;
- Rc is lower alkyl;
- Y3 is CH or N;
- Rd and Re are each independently H or lower alkyl;
- Rf is H or lower alkyl;
- Y4 is O or S;
- Y5 is CH or N;
- Y6 is CH or N;
- Rg is H or lower alkyl;
- R2 is H or lower alkyl;
- and
- either
- R3 and R4 are each independently H, halogen, lower alkyl, —O-lower alkyl, halogeno-lower alkyl, —O-halogeno-lower alkyl, cycloalkyl, or —CN,
- or
- R3 and R4 form 2,2-difluoro-1,3-benzodioxole with the benzene ring to which R3 and R4 are bonded.
20 more elements
Dependencies are inferred from the claim text.