Alpha-carbolines for the treatment of cancer

Compounds of formula (I)

• wherein:
• R1 is H or C1-C3 alkyl
• R2 is either halogen or
• X is either CH or N
• R3 is either C1-C3 alkyl or (1-methylpiperidin-4-yl)
• Rx and Ry are either H or nitro
• Rz and Rz′ are H, OH, or oxo
• Rt and R′t can be the same or different and are H or C1-C3 alkoxy
• Ra is H or F
• Rb is H, C1-C3 alkoxy, trifluoromethyl, or halogen
• Re is H or halogen
• Rf is H, C1-C3 alkyl or trifluoromethyl
• Rg is H or F
• Rk is H, halogen, trifluoromethyl, C1-C3 alkoxy, C1-C3 alkylsulfonamino
• Rl is H or F
• Rm is H, C1-C3 alkoxy, F or trifluoromethyl
• Rn is H, C1-C3 alkyl or a 5- to 6 -membered aromatic or heteroaromatic ring
• Rp is either C1-C3 alkyl or 5- to 6 -membered aromatic or heteroaromatic ring
• Rq is either H or tri(C1-C4)alkylsilyl
• Rs is tri(C1-C4)alkylsilyl
• Rh is either H , C1-C3 alkoxy or C1-C3 alkylcarbonylamino
• Ru is either H or F
• Rv is a C1-C3 alkyl
• Rw and Rw′ can be the same or different and are hydroxyl or C1-C3 alkoxy
• L and L′ are O, S, SO or SO2;
• Z is either C or N
• and pharmaceutically acceptable salts thereof.