US 9,428,496 B2Granted

Thiazolamine derivative and use thereof as anti-picornaviral infection medicament

AssigneeInstitute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China

InventorsSong Li, Hongliang Wang, Junhai Xiao, Xian Zhang, Lili Wang, Zhibing Zheng, Wu Zhong, Yunde Xie, Xingzhou Li, Xinbo Zhou, Guoming Zhao, Xiaokui Wang

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Abstract

Disclosed is as a substituted thiazolamine derivative represented by Formula I or a pharmaceutically acceptable salt thereof or a hydrate thereof (the definitions of each group in the formula are as presented in the description), and the application thereof in the prevention and/or treatment of viral diseases induced by picornavirus. Also disclosed is a pharmaceutical composition containing the compound.

Claims3

Dependent claims

A compound or a pharmaceutically acceptable salt or hydrate thereof, which is selected from the group consisting of:

2-{4-[5-(4-methoxyphenoxy)pentyl]-piperazin-1-yl}thiazole,
2-{4-[5-(4-ethoxyphenoxy)pentyl]piperazin-1-yl}thiazole,
2-{4-[5-(4-fluorophenoxy)pentyl]-piperazin-1-yl}thiazole,
2-{4-[5-(4-ethylphenoxy)pentyl]piperazin-1-yl}thiazole,
2-{4-[5-(4-isopropylphenoxy)pentyl]piperazin-1-yl}thiazole,
2-{4-[5-(4-tert-butylphenoxy)pentyl]piperazin-1-yl}thiazole,
2-{4-[5-(4-methylphenoxy)pentyl]piperazin-1-yl}thiazole,
2-{4-[6-(4-methylphenoxy)hexyl]piperazin-1-yl}thiazole,
2-{4-[6-(4-ethylphenoxy)hexyl]piperazin-1-yl}thiazole,
2-[4-(6-phenoxyhexyl)piperazin-1-yl]thiazole,
2-{4-[6-(4-tert-butylphenoxy)hexyl]piperazin-1-yl}thiazole,
2-{4-[6-(4-fluorophenoxy)hexyl]piperazin-1-yl}thiazole,
2-{4-[6-(4-chlorophenoxy)hexyl]piperazin-1-yl}thiazole,
2-{4-[6-(4-bromophenoxy)hexyl]piperazin-1-yl}thiazole,
2-{4-[5-(4-chlorophenoxy)pentyl]piperazin-1-yl}thiazole,
2-{4-[5-(4-bromophenoxy)pentyl]piperazin-1-yl}thiazole,
2-{4-[5-(4-bromophenoxy)pentyl]piperazin-1-yl}thiazole hydrochloride,
2-[4-(5-phenoxypentyl)piperazin-1-yl]thiazole hydrochloride,
2-{4-[6-(4-methoxyphenoxy)hexyl]piperazin-1-yl}thiazole hydrochloride,
2-{4-[6-(4-ethoxyphenoxy)hexyl]piperazin-1-yl}thiazole hydrochloride,
2-{4-[6-(4-ethylphenoxy)hexyl]piperazin-1-yl}thiazole hydrochloride, and
2-{4-[6-(4-isopropylphenoxy)hexyl]piperazin-1-yl}thiazole hydrochloride.

19 more elements

Dependencies are inferred from the claim text.

Facts

Application: 13/991,534Filed 6 Dec 2011
Priority: CN 2010 1 05745446 Dec 2010
Published: US 2014/0080840 A120 Mar 2014
Granted: 30 Aug 2016
Term ends: Not estimatedThe source records don’t support an estimate.

Classification13 codes

C07D 417/04
Containing two hetero rings: directly linked by a ring-member-to-ring-member bond
A61K 31/496
Having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines: non-condensed piperazines…
A61P 9/00
Drugs for disorders of the cardiovascular system
A61P 11/00
Drugs for disorders of the respiratory system