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US 9,428,489 B2Granted
Benzimidazole-carboxamide compounds as 5-HT4 receptor agonists
AssigneeTheravance Biopharma R&D IP, LLC
InventorsRobert Murray McKinnell, Lan Jiang, Daniel D. Long
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Abstract
The invention relates to benzimidazole-carboxamide 5-HT4 receptor agonist compounds of formula (I) wherein R1 and X are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The invention also relates to pharmaceutical compositions comprising such compounds, methods of using such compounds to treat diseases associated with 5-HT4 receptor activity, and processes and intermediates useful for preparing such compounds.
Claims8
A compound of formula (I′):
- wherein:
- R1 is C3-4alkyl;
- and
- R3 is phenyl, optionally substituted with 1 or 2 substituents selected from methyl, chloro, fluoro, and —CF3,
- or a pharmaceutically-acceptable salt or stereoisomer thereof.
2 more elements
Dependencies are inferred from the claim text.