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US 9,428,488 B2Granted
Method for producing 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile, and intermediate thereof
AssigneeFujiyakuhin Co., Ltd.
InventorsYoshiyuki Iwabuchi, Sachiho Miyata, Junichiro Uda, Osamu Nagata
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Abstract
To provide an industrially useful method for producing pharmaceutically useful 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile, and an intermediate for producing the compound. The method for producing compound represented by formula (1) is represented by the following reaction scheme, and the intermediate is represented by the following formula (4).
Claims17
A method for producing 4-[5-(pyridin-4-yl)-1H-1,2,4-triazol-3-yl]pyridine-2-carbonitrile of formula (1):
- the method comprising reacting a compound of formula (2):
- with isonicotinic acid hydrazide in the presence of an alkali metal alkoxide, to thereby form a compound of formula (3):
- cyanating the compound (3) with at least one cyanating agent selected from the group consisting of an alkali metal cyanide, zinc cyanide, and a trialkyl cyanide, to thereby form a compound of formula (4):
- and subjecting the compound (4) to a ring-closure reaction in the presence of at least one acid catalyst selected from the group consisting of an organic acid catalyst and an inorganic acid catalyst.
1 more element
Dependencies are inferred from the claim text.