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AssigneeMerck Sharp & Dohme Corp.
InventorsJack D. Scott, Andrew W. Stamford, Eric J. Gilbert, Jared N. Cumming
Estimating the term…
In its many embodiments, the present invention provides certain iminothiadiazine dioxide compounds, including compounds Formula (I): (I) and include stereoisomers thereof, and pharmaceutically acceptable salts of said compounds stereoisomers, wherein each of R1, R2, R3, R4, R5, R9, ring A, ring B, m, n, p, -L1-, L2-, and L3- is selected independently and as defined herein. The novel iminothiadiazine dioxide compounds of the invention have surprisingly been found to exhibit properties which are expected to render them advantageous as BACE inhibitors and/or for the treatment and prevention of various pathologies related to β-amyloid (Aβ) production. Pharmaceutical compositions comprising one or more such compounds (alone and in combination nation with one or more other active agents), and methods for their preparation and use in treating pathologies associated with amyloid beta (Aβ) protein, including Alzheimers disease, are also disclosed.
A method of treating Alzheimer's disease in a human in need thereof comprising administering to the human a therapeutically effective amount of a compound, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer, said compound selected from the group consisting of:
A method of treating Alzheimer's disease in a human in need thereof comprising administering to the human a therapeutically effective amount of a compound having a structure:
A method of treating Alzheimer's disease in a human in need thereof comprising administering to the human a therapeutically effective amount of a compound having a structure:
A method of treating mild cognitive impairment in a human in need thereof comprising administering to the human a therapeutically effective amount of a compound, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer, said compound selected from the group consisting of:
A method of treating mild cognitive impairment in a human in need thereof comprising administering to the human a therapeutically effective amount of a compound having a structure:
A method of treating mild cognitive impairment in a human in need thereof comprising administering to the human a therapeutically effective amount of a compound having a structure:
A method of lowering the production of Aβ40 in the cerebral cortex of a human in need thereof comprising administering to the human a therapeutically effective amount of a compound, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer, said compound selected from the group consisting of:
A method of lowering the production of Aβ40 in the cerebral cortex of a human in need thereof comprising administering to the human a therapeutically effective amount of a compound, having a structure:
A method of lowering the production of Aβ40 in the cerebral cortex of a human in need thereof comprising administering to the human a therapeutically effective amount of a compound having a structure:
A method of inhibiting the formation of AP peptides in a human in need thereof, which method comprises administering to the human a therapeutically effective amount of a compound, or a tautomer thereof, or a pharmaceutically acceptable salt of said compound or said tautomer, wherein said compound is selected from the group consisting of:
A method of inhibiting the formation of AP peptides in a human in need thereof comprising administering to the human a therapeutically effective amount of a compound having a structure:
A method of inhibiting the formation of Aβ peptides in a human in need thereof, which method comprises administering to the human a therapeutically effective amount of a compound having a structure:
Dependencies are inferred from the claim text.