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US 9,428,474 B2Granted
Antibacterial compounds
AssigneeJanssen Sciences Ireland UC
InventorsJérôme Émile Georges Guillemont, Magali Madeleine Simone Motte, Anil Koul, Nacer Lounis
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Abstract
The present invention relates to the following compounds for use in the treatment of a bacterial infection wherein the integers are as defined in the description. The invention also relates to compounds for use as medicaments, pharmaceutical compositions and some novel compounds.
Claims6
A compound of formula (I):
- wherein
- R1, R2, R3 and R4 each independently are selected from the group consisting of:
- hydrogen, halo, —CN, Rt1, —O—Rt2, —C(O)N(Rt3)(Rt4), —SO2Rt5, —N(H)SO2Rt6, —N(Rt7)(Rt8), aryl and heterocyclic group wherein said aryl and said heterocyclic group optionally substituted by one or more substituents selected from halo and C1-6 alkyl;
- Rt1, Rt2, Rt3, Rt4, Rt5, Rt6, Rt7 and Rt8 independently are hydrogen or C1-6 alkyl wherein said C1-6 alkyl is optionally substituted by one or more halo atoms, or, Rt3 and Rt4 and/or Rt7 and Rt8 may be linked together with the nitrogen atom to which they are attached to form a 3- to 7-membered ring, optionally containing one to three additional heteroatoms and optionally contain one to three double bonds;
- Zx is O or S;
- X is S or O;
- ring A is either:
- Rx is hydrogen or C1-6 alkyl wherein said C1-6 alkyl is optionally substituted by one or more substituents selected from the group consisting of fluoro, —CN, —ORx1, and —C(O)Rx2;
- Rx1 and Rx2 independently are hydrogen or C1-6 alkyl;
- Ry3 independently is hydrogen, halo, C1-6 alkyl, —ORy4, —C(O)—Ry5 or —CH2—ORy6;
- Ry4, Ry5 and Ry6 independently are hydrogen or C1-6 alkyl;
- wherein Ry1 is fluoro, chloro, C1-6 alkyl, —OH, —C(O)Ry5 or —CH2—ORy6;
- and Ry2 is —OH, C1-6 alkyl, —C(O)Ry5 or —CH2—ORy6
- or a pharmaceutically acceptable salt thereof.
11 more elements
Dependencies are inferred from the claim text.