Methods of treating bacterial infections with 1,2-benzisothiazolinone and isoindolinone derivatives

A method of treating a bacterial infection to a subject, wherein a composition comprising a compound of the following formula:

• or a pharmaceutically acceptable salt or prodrug, is administered to the subject, wherein:
• R1 is hydrogen or methyl;
• W is —C(O)NR2— or —C(O)NR3—NR4C(O)—, wherein R2, R3, and R4 are each independently selected from hydrogen, substituted or unsubstituted C1-12 alkyl, substituted or unsubstituted C1-12 haloalkyl, substituted or unsubstituted C2-12 alkenyl, substituted or unsubstituted C2-12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted cycloalkylalkyl, and substituted or unsubstituted heterocycloalkylalkyl;
• and
• Y is hydrogen, hydroxy, alkoxy, substituted or unsubstituted amino, substituted or unsubstituted thio, substituted or unsubstituted C1-12 alkyl, substituted or unsubstituted C1-12 haloalkyl, substituted or unsubstituted C2-12 alkenyl, substituted or unsubstituted C2-12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted cycloalkylalkyl, or substituted or unsubstituted heterocycloalkylalkyl.

A method of treating a bacterial infection in a subject, wherein a composition comprising a compound of the following formula:

• or a pharmaceutically acceptable salt or prodrug, is administered to the subject, wherein:
• R1 is hydrogen or methyl;
• W is —C(O)NR2—, —C(O)NR3—NR4C(O)—, or
• wherein R2, R3, and R4 are each independently selected from hydrogen, substituted or unsubstituted C1-12 alkyl, substituted or unsubstituted C1-12 haloalkyl, substituted or unsubstituted C2-12 alkenyl, substituted or unsubstituted C2-12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted cycloalkylalkyl, and substituted or unsubstituted heterocycloalkylalkyl;
• X is CH2 or S;
• Y is hydrogen, hydroxy, alkoxy, substituted or unsubstituted amino, substituted thio, substituted or unsubstituted C1-12 alkyl, substituted or unsubstituted C1-12 haloalkyl, substituted or unsubstituted C2-12 alkenyl, substituted or unsubstituted C2-12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted cycloalkylalkyl, or substituted or unsubstituted heterocycloalkylalkyl;
• and
• Z is C═O or SO2.

A method of treating a bacterial infection in a subject, wherein a composition comprising a compound of the following formula:

• or a pharmaceutically acceptable salt or prodrug, is administered to the subject, wherein:
• R1 is hydrogen or methyl;
• W is —C(O)NR2—, —C(O)NR3—NR4C(O)—, or
• wherein R2, R3, and R4 are each independently selected from hydrogen, substituted or unsubstituted C1-12 alkyl, substituted or unsubstituted C1-12 haloalkyl, substituted or unsubstituted C2-12 alkenyl, substituted or unsubstituted C2-12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted cycloalkylalkyl, and substituted or unsubstituted heterocycloalkylalkyl;
• and
• Y is hydrogen, hydroxy, alkoxy, substituted or unsubstituted amino, substituted thio, substituted or unsubstituted C1-12 alkyl, substituted or unsubstituted C1-12 haloalkyl, substituted or unsubstituted C2-12 alkenyl, substituted or unsubstituted C2-12 alkynyl, substituted or unsubstituted aryl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted arylalkyl, substituted or unsubstituted heteroarylalkyl, substituted or unsubstituted cycloalkylalkyl, or substituted or unsubstituted heterocycloalkylalkyl.