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US 9,428,468 B2Granted
Process for the preparation of erlotinib
AssigneeCerbios-Pharma SA
InventorsMarco Baratella, Giuseppe Pallanza, Mauro Gaboardi, Graziano Castaldi
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Abstract
A process for the preparation of Erlotinib is disclosed in which the compound of formula (II) Is reacted with the compound of formula (III) in the presence of trifluoroacetic acid and formamidine acetate, in an aprotic solvent, and the reaction product is subsequently treated with a source of hydrochloric acid in a suitable solvent to give Erlotinib hydrochloride.
Claims10
A process for the synthesis of Erlotinib hydrochloride, comprising:
- a) reacting the compound of formula (II)
- with the compound of formula (III)
- and
- b) subsequently treating the reaction product of step a) with a source of hydrochloric acid in a suitable solvent to give Erlotinib hydrochloride,
- wherein the reacting of the compound of formula (II) with the compound of formula (III) is carried out in the presence of trifluoroacetic acid and formamidine acetate, in an aprotic solvent.
2 more elements
Dependencies are inferred from the claim text.