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US 9,428,465 B2Granted
Acid ceramidase inhibitors and their use as medicaments
AssigneeFondazione Istituto Italiano Di Technologia
InventorsDaniele Piomelli, Natalia Realini, Marco Mor, Chiara Pagliuca, Daniela Pizzirani, Rita Scarpelli, Tiziano Bandiera
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Abstract
The present invention concerns, in a first aspect, compounds of Formula I as defined herein, pharmaceutically acceptable salts thereof and pharmaceutical compositions containing such compounds. The present invention also relates to compounds of Formula I for use as acid ceramidase inhibitors, and in the treatment of cancer and other disorders in which modulation of the levels of ceramide is clinically relevant.
Claims5
A compound of Formula Ib or pharmaceutically acceptable salt thereof
- wherein
- A represents O;
- Y represents C1-C8 alkyl;
- W represents hydrogen;
- R1 represents hydrogen;
- R2 represents trifluoromethyl, an optionally substituted heterocyclyl, an optionally substituted aryl, an optionally substituted heteroaryl, or a group selected from O—R6 and NR7R8;
- R3 represents hydrogen;
- R6 represents an optionally substituted C1-C8 alkyl;
- and
- R7 and R8 independently represent hydrogen, an optionally substituted C1-C6 alkyl, a group (C═O) aryl, or, when taken together with the nitrogen atom to which they are bound, an optionally substituted heterocyclyl.
7 more elements
Dependencies are inferred from the claim text.