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US 9,428,460 B2Granted
N-[4-(quinolin-4-yloxy)cyclohexyl(methyl)](hetero)arylcarboxamides as androgen receptor antagonists, production and use thereof as medicinal products
AssigneeBayer Pharma Aktiengesellschaft
InventorsDuy Nguyen, Hermann Künzer, Hortensia Faus Gimenez, Benjamin Bader, Silke Köhr, Martin Fritsch
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Abstract
The invention relates to N-[4-(quinolin-4-yloxy)cyclohexyl(methyl)](hetero)arylcarboxamides, intermediates and methods for their production, use thereof for treating and/or preventing diseases and use thereof for producing medicinal products and use thereof for treating and/or preventing diseases, especially of hyperproliferative diseases.
Claims23
A compound of formula (I)
- in which
- R1 stands for H, cyano, fluorine, chlorine or bromine;
- A stands for phenyl or 5-membered heteroaryl, wherein the phenyl or the 5-membered heteroaryl is optionally substituted with one, two or three substituents selected independently of one another from:
- halogen, cyano, alkyl-, haloalkyl-, cycloalkyl-, heterocyclyl-, hydroxy, alkoxy-, fluoroalkoxy-, cycloalkyloxy-, amino-, alkylamino-, dialkylamino-, cycloalkylamino-, alkylcycloalkylamino-, dicycloalkylamino-, alkylcarbonylamino-, cycloalkylcarbonylamino-, alkylsulphanyl-, cycloalkylsulphanyl-, alkylsulphonyl-, cycloalkylsulphonyl-, aminosulphonyl-, alkylaminosulphonyl-, cycloalkylaminosulphonyl-;
- and alkoxycarbonyl-;
- n=0, 1 or 2;
- or a salt thereof.
4 more elements
A compound of formula (II)
- in which R1 stands for H, cyano, fluorine, chlorine or bromine and n is 0, 1, or 2.
Dependencies are inferred from the claim text.