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US 9,428,447 B2Granted
Bis-(aryl/heteroaryl)-methylene compounds, pharmaceutical compositions containing same and their use for treating cancer
AssigneeThe Royal Institution for the Advancement of Learning/Mcgill University
InventorsJames L. Gleason, John H. White, Dainis Kaldre, Joshua Fischer
Life of this patent
Estimating the term…
Abstract
The present disclosure relates to novel compounds having vitamin D receptor agonist and histone deacetylase inhibitory efficacy as well as methods for reducing or inhibiting the proliferation of cancer cells or for treating cancer.
Claims18
A compounds of formula
- or a pharmaceutically acceptable salt thereof, wherein
- the dotted line is an optional double bond;
- A and B are each independently an aryl;
- R1 is hydrogen, an alkyl or cycloalkyl;
- R2 is absent when the dotted line is a double bond or R2 is hydrogen, an alkyl or cycloalkyl when the dotted line is absent;
- W is OH when the dotted line is absent or W is O when the dotted line is a double bond;
- X is O, CH2, CHR7 or CR7R7, where R7 is in an alkyl or fluoroalkyl;
- Y is NR10(CO), (CO)NR10, O, CH2, CHR7 or CR7R7, where R7 is in an alkyl or fluoroalkyl and R10 is H or an alkyl;
- R3 and R4 are each independently hydrogen, an alkyl or fluoroalkyl;
- R5 and R6 are each independently an optional substituent;
- when p is greater than 0, R″ is H and one of said R″ is optionally OH;
- n and p are each an integer from 0 to 6.
9 more elements
The compound of 1, or a pharmaceutically acceptable salt thereof, wherein R1 is an alkyl or cycloalkyl and R2 is hydrogen, an alkyl or cycloalkyl.
A compound selected from the following list:
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.