Hydrobenzamide derivatives as inhibitors of Hsp90
AssigneeAstex Therapeutics Limited
InventorsMartyn Frederickson, John Francis Lyons, Neil Thomas Thompson, Mladen Vinkovic, Brian John Williams, Andrew James Woodhead, Alison Jo-Anne Woolford
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Abstract
The invention provides an acid addition salt of a compound of the formula (1). Also provided by the invention are processes for preparing the compound of formula (1) and alkyl analogs thereof, novel intermediates for use in the process and methods for preparing the intermediates. The invention also provides new medical uses of compounds of the formula (1) and its ethyl analog.
Claims11
A method for reducing cancer in a mammal, the method comprising administering to the mammal an effective amount of an acid addition salt of a compound of the formula (1):
- which is a salt formed with lactic acid, wherein said cancer is selected from:
- carcinoma of the bladder, breast, colon, kidney, epidermis, liver, lung, ovary, pancreas, stomach, thyroid, prostate, gastrointestinal system, skin, a hematopoietic tumor of lymphoid or myeloid lineage, and a tumor of the central or peripheral nervous system.
A method for reducing cancer in a mammal, the method comprising administering to the mammal a pharmaceutical composition comprising an effective amount of an acid addition salt of a compound of the formula (1):
- which is a salt formed with lactic acid, and a pharmaceutically acceptable carrier, wherein said cancer is selected from:
- carcinoma of the bladder, breast, colon, kidney, epidermis, liver, lung, ovary, pancreas, stomach, thyroid, prostate, gastrointestinal system, skin, a hematopoietic tumor of lymphoid or myeloid lineage, and a tumor of the central or peripheral nervous system.
Dependencies are inferred from the claim text.