Bone pastes comprising biofunctionalized calcium phosphate cements with enhanced cell functions for bone repair
AssigneeUniversity of Maryland, Baltimore
InventorHuakun Xu
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Abstract
The invention provides injectable, biofunctional agent-containing calcium phosphate cement bone pastes for bone tissue engineering, and methods of making and using the same.
Claims23
A bone paste comprising calcium phosphate cement, one or more biofunctional agents and stem cells, wherein the biofunctional agents are selected from the group consisting of RGD-containing peptides, fibronectin, fibronectin-like engineered polymer protein (FEPP), derived extracellular matrix (dECM), and platelet concentrate, and wherein the stem cells are selected from the group consisting of human umbilical cord mesencchymal stem cells, bone marrow stem cells, embryonic stem cells, pluripotent stem cells, induced pluripotent stem cells, multipotent stem cells, progenitor cells, and osteoblasts.
Dependencies are inferred from the claim text.