Radioisotope trithiol complexes
AssigneeThe Curators of the University of Missouri
InventorsSilvia S. Jurisson, Cathy S. Cutler, Anthony J. Degraffenreid
Life of this patent
Estimating the term…
Abstract
The present invention is directed to a series of stable radioisotope trithiol complexes that provide a simplified route for the direct complexation of radioisotopes present in low concentrations. In certain embodiments, the complex contains a linking domain configured to conjugate the radioisotope trithiol complex to a targeting vector. The invention is also directed to a novel method of linking the radioisotope to a trithiol compound to form the radioisotope trithiol complex. The inventive radioisotope trithiol complexes may be utilized for a variety of applications, including diagnostics and/or treatment in nuclear medicine.
Claims20
A radioisotope trithiol complex according to Formula I:
- wherein each R1 is independently C1 to C5 substituted or unsubstituted hydrocarbyl;
- mM is a radioisotope;
- and
- X is a chemical moiety.
A radioisotope trithiol complex according to Formula I:
- wherein each R1 is a C1 to C5 substituted or unsubstituted hydrocarbyl having the same number of carbon atoms;
- mM is a radioisotope;
- and
- X is a linking domain comprising a functional group.
Dependencies are inferred from the claim text.