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US 9,427,479 B2Granted
Tubulysin derivatives
AssigneeMedImmune, LLC
InventorsLakshmaiah Gingipalli, Dorin Toader, Fengjiang Wang
Life of this patent
Estimating the term…
Abstract
Novel tubulysin derivatives which may be useful as cytotoxic agents to provide therapeutic benefits in the treatment of various types of cancers, alone, as drug conjugates or in combination with other chemotherapies are provided.
Claims41
A compound having the structure of Formula I:
- or a pharmaceutically acceptable salt thereof,
- wherein:
- R1 is CH3 or CH2CH3,
- R2 is H or CH3,
- R3 is H or NH2 and
- n is 1 or 2.
3 more elements
A compound having the structure of Formula II
- or a pharmaceutically acceptable salt thereof,
- wherein:
- R1 is CH3 or CH2 CH3,
- R2 is H or CH3,
- R4 is CH3, (CH2)4NH2, or (CH2)3NHC(═O)NH2,
- R5 is H or CH(CH3)(CH3),
- R6 is NHC(═O) or CH2,
- n is 1 or 2;
- and
- m is 0, 1, 2 or 3.
7 more elements
A antibody-drug conjugate which is a conjugate of a compound having the structure of Formula II
- wherein:
- R1 is CH3 or CH2 CH3,
- R2 is H or CH3,
- R4 is CH3, (CH2)4NH2, or (CH2)3NHC(═O)NH2,
- R5 is H or CH(CH3)(CH3),
- R6 is NHC(═O) or CH2,
- n is 1 or 2;
- and
- m is 0, 1, 2 or 3;
- and an antibody.
7 more elements
A compound having the Formula (IIiv)
An antibody-drug conjugate which is a conjugate of a compound of the Formula (IIiv)
Dependencies are inferred from the claim text.