Multivalent meningococcal conjugates and methods for preparing conjugates
AssigneesThe United States of America, as represented by the Secretary, Department of Health and Human Services, The United States of America as represented by the Secretary of the Army
InventorsChe-Hung Robert Lee, Valerian B. Pinto
Life of this patent
Estimating the term…
Abstract
Disclosed herein are meningococcal immunogenic conjugates which can elicit immune responses against meningococcal polysaccharides (PS) from groups A, C, W-135, and Y and group B factor H binding protein (fHbp). The disclosed conjugates also exhibit bactericidal activity against meningococcal A, C, W-135, Y, B, and X serogroups. Also disclosed are improved methods for preparing conjugates, such as immunogenic conjugates, including activation of a polysaccharide with a cyanylation agent at about 4° C.
Claims6
A pharmaceutical composition comprising:
- an immunogenic conjugate comprising a Meningococcal group A polysaccharide conjugated to an fHbp fusion protein comprising the amino acid sequence SEQ.ID.NO:8;
- an immunogenic conjugate comprising a Meningococcal group C polysaccharide conjugated to an fHbp fusion protein comprising the amino acid sequence SEQ.ID.NO:8;
- an immunogenic conjugate comprising a Meningococcal group W polysaccharide conjugated to an fHbp fusion protein comprising the amino acid sequence SEQ.ID.NO:8;
- and
- an immunogenic conjugate comprising a Meningococcal group Y polysaccharide conjugated to an fHbp fusion protein comprising the amino acid sequence SEQ.ID.NO:8.
Dependencies are inferred from the claim text.