Glucose-responsive insulin conjugates
AssigneeMerck Sharp & Dohme Corp.
InventorsSongnian Lin, Lin Yan, Pei Huo
Life of this patent
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Abstract
Insulin conjugates comprising an insulin molecule covalently attached to at least one bi-dentate linker having two arms, each arm independently attached to a ligand comprising a saccharide and wherein the saccharide for at least one ligand of the linker is fucose are disclosed. The insulin conjugates display a pharmacokinetic (PK) and/or pharmacodynamic (PD) profile that is responsive to the systemic concentrations of a saccharide such as glucose or alpha-methylmannose even when administered to a subject in need thereof in the absence of an exogenous multivalent saccharide-binding molecule such as Con A.
Claims4
A method for treating a subject who has diabetes comprising:
- administering to the subject an amount of a composition comprising a conjugate having the formula
- wherein insulin refers to human insulin, and a pharmaceutically acceptable carrier;
- wherein said administering treats the diabetes.
Dependencies are inferred from the claim text.