Controlled release compositions for modulating free-radical induced damage and methods of use thereof
AssigneesOtonomy, Inc., The Regents of the University of California
InventorsJay Lichter, Andrew M. Trammel, Fabrice Piu, Qiang Ye, Sergio G. Duron, Luis A. Dellamary, Carl Lebel, Jeffrey P. Harris
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Abstract
Disclosed herein are compositions and methods for the treatment of otic diseases or conditions with free-radical modulating agent compositions and formulations administered locally to an individual afflicted with an otic disease or condition, through direct application of these compositions and formulations onto or via perfusion into the targeted auris structure(s).
Claims15
An intratympanic composition for use in the treatment of an otic disease or condition associated with free-radical induced damage, the intratympanic composition comprising
- a micronized free-radical modulating agent, or pharmaceutically acceptable prodrug or salt thereof;
- and
- an auris acceptable gel,
- wherein the micronized free-radical modulating agent, or pharmaceutically acceptable prodrug or salt thereof is not provided as polymer-containing particles, and is suspended in the auris acceptable gel;
- and wherein sustained release of the free-radical modulating agent into the ear occurs for a period of at least 5 days after a single administration.
Dependencies are inferred from the claim text.