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US 9,427,469 B2Granted
Soluble physiological chitosan formulations combined with platelet-rich plasma (PRP) for tissue repair
AssigneeOrtho Regenerative Technologies Inc.
InventorsWei Ouyang, Michael Buschmann, Anik Chevrier
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Abstract
The present disclosure relates to an activated polymer composition for use in repairing tissue of a patient comprising platelet-rich plasma (PRP), a chitosan solution, a salt such as NaCI or glycerol phosphate, and an activator such as at least one of CaCI2 and a mixture of thrombin/CaCI2.
Claims16
A clot-activated polymer composition comprising:
- a) anti-coagulated platelet-rich plasma (PRP) selected from the group consisting of autologous, allogenic, xenogenic and combinations thereof;
- and
- b) a chitosan, an acid, NaCl and a clot activator comprising a 3% calcium chloride (CaCl2) solution
- wherein the polymer composition comprises a pH above 6.2 and an osmolality between 300 mOsm/kg and 735 mOsm/kg,
- wherein the polymer composition is substantially free of whole blood and added thrombin,
- wherein the clot-activated polymer composition is prepared by combining said PRP to a chitosan solution at a volume ratio of between 2:1 to 3:1,
- and wherein said chitosan solution comprises said chitosan and said NaCl.
4 more elements
Dependencies are inferred from the claim text.