Compositions and methods for diagnosing and treating community-acquired methicillin-resistant Staphylococcus aureus
AssigneeTrustees of Dartmouth College
InventorsAmbrose Cheung, Guido Memmi
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Abstract
The present invention includes compositions and methods for diagnosing and treating CA-MRSA infections in patients. The methods are based on the finding that combining cefoxitin and a synthetic penicillin in a treatment regimen results in a synergistic effect of the two drugs, an effect that is related to PBP4 activity in CA-MRSA isolates. Also provided is a CA-MRSA-specific biomarker which can be used to detect the presence of a CA-MRSA infection in a patient.
Claims3
A topical composition for treating a CA-MRSA infection in a patient consisting of an effective amount of cefoxitin and an effective amount of oxacillin in a pharmaceutically acceptable vehicle, wherein said vehicle is suitable for topical application to the skin of a patient with a CA-MRSA infection, and further wherein said vehicle is White Petrolatum.
Dependencies are inferred from the claim text.