Anti-human TROP-2 antibody having an antitumor activity in vivo
AssigneeChiome Bioscience Inc.
InventorsKoji Nakamura, Kentaro Okamura, Maki Tamura, Hiroyuki Yanai, Toru Kanke, Naoya Tsurushita, Shankar Kumar
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Abstract
The present invention provides: an antibody which specifically reacts with hTROP-2 and has anti-tumor activity in vivo (particularly, a humanized antibody); a hybridoma which produces the aforementioned antibody; a conjugate of the aforementioned antibody and a drug; a pharmaceutical composition for diagnosing or treating a tumor; a method for detecting a tumor; and a kit for detecting or diagnosing a tumor.
Claims10
An isolated antibody that binds human TROP-2 comprising a heavy chain variable region consisting of the amino acid sequence of SEQ ID NO:
- 94 or SEQ ID NO:
- 95, and a light chain variable region consisting of the amino acid sequence of SEQ ID NO:
- 96.
An isolated antibody that binds human TROP-2 comprising a heavy chain variable region consisting of the amino acid sequence of SEQ ID NO:
- 94 or SEQ ID NO:
- 95, and a light chain variable region consisting of the amino acid sequence of SEQ ID NO:
- 96, wherein said antibody exhibits 50% or more of tumor growth inhibitory activity in vivo at a dosage of 5 to 20 mg/kg body weight in comparison to growth of a control untreated tumor.
An isolated antibody that binds human TROP-2 comprising a heavy chain variable region consisting of the amino acid sequence of SEQ ID NO:
- 94 or SEQ ID NO:
- 95, and a light chain variable region consisting of the amino acid sequence of SEQ ID NO:
- 96, wherein said antibody exhibits 50% or more of tumor growth inhibitory activity in vivo at a dosage of 10 mg/kg body weight in comparison to growth of a control untreated tumor.
An isolated antibody that binds human TROP-2 comprising a heavy chain variable region consisting of the amino acid sequence of SEQ ID NO:
- 94 or SEQ ID NO:
- 95, and a light chain variable region consisting of the amino acid sequence of SEQ ID NO:
- 96, wherein said antibody is a monoclonal antibody.
An isolated antibody antigen-binding fragment comprising the amino acid sequence of SEQ ID NO:
- 94 or SEQ ID NO:
- 95 and the amino acid sequence of SEQ ID NO:
- 96.
A pharmaceutical composition comprising an antibody that binds human TROP-2 and a pharmaceutically acceptable carrier, wherein said antibody comprises a heavy chain variable region consisting of the amino acid sequence of SEQ ID NO:
- 94 or SEQ ID NO:
- 95, and a light chain variable region consisting of the amino acid sequence of SEQ ID NO:
- 96.
A diagnostic agent comprising an antibody that binds human TROP-2, said antibody comprising a heavy chain variable region consisting of the amino acid sequence of SEQ ID NO:
- 94 or SEQ ID NO:
- 95, a light chain variable region consisting of the amino acid sequence of n SEQ ID NO:
- 96, and a detectable label.
Dependencies are inferred from the claim text.