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AssigneeNational University Corporation Chiba University
InventorsIssei Komuro, Ichiro Shiojima, Weidong Zhu
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Provided is a novel soluble factor that modulates morphogenesis and cell proliferation, such as cardiac development and/or cardiomyocyte differentiation. Specifically provided are: an inhibitor of Wnt signalling, comprising an insulin-like growth-factor-binding protein (IGFBP), the protein being binding to a Wnt receptor, and/or a polynucleotide encoding the protein; a medicament for prevention and/or treatment of a disease due to enhanced Wnt signalling, comprising the inhibitor of Wnt signalling, and a medicament for induction of cardiomyocyte differentiation; and a method for prevention and/or treatment of a disease due to enhanced Wnt signalling and a method of inducing cardiomyocyte differentiation, the methods each comprising using the inhibitor of Wnt signalling, and a cardiomyocyte, which is obtained by the method of inducing cardiomyocyte differentiation, and a use thereof.
A method of inhibiting Wnt signalling, comprising contacting an insulin-like growth-factor-binding protein (IGFBP) with a Wnt receptor in vitro, wherein the insulin-like growth-factor-binding protein (IGFBP) is a protein represented by an amino acid sequence set forth in SEQ ID NO:
Dependencies are inferred from the claim text.