Therapeutic immune modulation by stem cell secreted exosomes
AssigneeXON Cells, Inc.
InventorsThomas Ichim, Vladimir Bogin
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Abstract
Disclosed are methods, compositions of matter, and protocols useful for the induction of a therapeutic immune modulatory response through administration of exosomes derived from a stem cell source. In one embodiment, said stem cell source is endometrial regenerative cells. Specifically, in one embodiment stem cell derived exosomes are used as a method of treating an autoimmune condition such as rheumatoid arthritis, multiple sclerosis, or systemic lupus erythromatosis.
Claims18
A method of enhancing stem cell engraftment in a mammal comprising the steps of:
- a) extracting a stem cell population;
- b) culturing said stem cell population for a sufficient time point, under conditions permissible for exosome production;
- c) collecting exosomes generated by said stem cell population;
- d) concentrating said exosomes;
- and
- e) administering said exosomes and said stem cells to said mammal.
A method of enhancing stem cell engraftment in a mammal comprising
- a) extracting a stem cell population;
- b) culturing said stem cell population for a sufficient time point, under conditions permissible for exosome production;
- c) collecting exosomes generated by said stem cell population;
- d) concentrating said exosomes to at least 1 μg/mL;
- and
- e) administering 1-2 μg of said exosomes and at least 100,000 of said stem cells to the mammal.
A method of treating a cardiac enhancing stem cell engraftment in a human patient in need of therapy comprising:
- a) obtaining a mesenchymal stem cell;
- b) introducing into said mesenchymal stem cell an antigen, wherein said antigen is present in one or more exosomes released by said mesenchymal stem cell;
- c) purifying said exosomes and concentrating said exosomes to at least 1 μg/mL;
- d) administering an amount of said exosomes and an amount of said stem cells into the human patient in need of therapy effective to inhibit T cell proliferation.
Dependencies are inferred from the claim text.