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US 9,427,443 B2Granted
Anaesthetic composition
AssigneeJurox Pty Ltd
InventorsPeter John Kieran, Kai Kin Lau, Barry Edward Patten
Life of this patent
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Abstract
A stable anaesthetic composition is described which is particularly suitable for use in cats and dogs. The composition comprises an aqueous solution of an anaesthetically effective amount of water soluble cyclodextrin or a cyclodextrin derivative complex of alfaxalone and a bugger, excluding phosphate buffer pH 7.0, 0.1 M mixed as defined in the British Pharmacopoeia 1998, such that the pH of the solution is from 6.0-8.0.
Claims7
An anaesthetic composition, comprising:
- an aqueous solution of an anaesthetically effective amount of a water soluble cyclodextrin or a cyclodextrin derivative complex of alfaxalone and buffer effective to stabilise the alfaxalone and provide a pH in the composition of about 6.8, wherein
- crystalline material does not form in the composition within about 7 days when stored at 40° C., and
- the water soluble cyclodextrin or cyclodextrin derivative is 2-hydroxypropyl beta-cyclodextrin, and
- the alfaxalone in a concentration of 7-15 mg/mL.
1 more element
A method of producing a packaged sterile anaesthetic composition, comprising:
- forming an aqueous solution of a 2-hydroxypropyl beta cyclodextrin complex with alfaxalone and a buffer;
- introducing the solution into a container;
- sterilizing the solution and the container by autoclaving;
- wherein,
- the solution has a pH of about 6.8;
- the concentration of alfaxalone is 7-15 mg/mL;
- the composition has a shelf life of at least 6 months when stored below 30° C.;
- and
- crystalline material does not form in the composition within about 7 days when stored at 40° C.
6 more elements
Dependencies are inferred from the claim text.