Methods and compositions for enhancing fertility and/or inhibiting pregnancy failure and restoring glucose tolerance
AssigneeQueen's University at Kingston
InventorsAhmad J. H. Albaghdadi, Frederick W. K. Kan
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Abstract
Methods and compositions for enhancing fertility and/or inhibiting pregnancy failure, restoring glucose tolerance and/or preventing glucose intolerance and/or maintaining glucose homeostasis and/or inducing or enhancing weight loss, treating dyslipidemia, treating hypertestosteronism or hyperandrogenism, and/or treating type 2 diabetes in an individual in need thereof are provided. These involve compositions that inhibit expression of interferon-gamma (IFN-γ) or a downstream IFN-γ-stimulated gene, which is preferably a macrolide immunosuppressant compound.
Claims8
A method for enhancing fertility and/or inhibiting pregnancy failure in an individual in need thereof comprising administering to the individual a composition comprising a macrolide immunosuppressant, wherein said individual has hyperglycemia, impaired fasting glycemia, type 2 diabetes, gestational diabetes, polycystic ovarian syndrome, recurrent miscarriages, is pre-diabetic, is undergoing in vitro fertilization (IVF), and/or is obese.
Dependencies are inferred from the claim text.