Benzimidazole-imidazole derivatives
AssigneeJanssen Sciences Ireland UC
InventorsKoen Vandyck, Stefaan Julien Last, Ioannis Nicolaos Houpis, Pierre Jean-Marie Bernard Raboisson
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Abstract
Inhibitors of HCV replication of formula I including stereochemically isomeric forms, and salts, solvates thereof, wherein R and R′ are, each independently, —CR1R2R3, aryl, heteroaryl or heteroC4-6cycloalkyl, whereby aryl and heteroaryl may optionally be substituted with 1 or 2 substituents selected from halo and methyl. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use in HCV therapy.
Claims32
A compound of formula I
- or a stereoisomeric form thereof, wherein:
- A is naphthylene, which is optionally substituted with 1, 2 or 3 substituents selected from halo and C1-3alkyl;
- R and R′ are, each independently, —CR1R2R3, aryl, heteroaryl or heteroC4-6cycloalkyl, whereby aryl and heteroaryl may optionally be substituted with 1 or 2 substituents selected from halo and methyl;
- and wherein
- R1 is hydrogen;
- C1-4alkyl optionally substituted with methoxy or dimethylamino;
- phenyl optionally substituted with 1, 2 or 3 substituents independently selected from halo, C1-4alkoxy, and trifluoromethoxy;
- 1,3-benzodioxolanyl;
- benzyl optionally substituted with 1, 2 or 3 substituents independently selected from halo and methoxy;
- C3-6cycloalkyl;
- heteroaryl;
- heteroC4-6cycloalkyl;
- or
- heteroarylmethyl;
- R2 is hydrogen, hydroxyl, amino, mono- or di-C1-4alkylamino, C1-4alkylcarbonylamino, C1-4alkyloxycarbonylamino, C1-4alkylaminocarbonylamino, piperidin-1-yl or imidazol-1-yl;
- R3 is hydrogen,
- or R1 and R3 together form a cyclopropyl group;
- or R2 and R3 form oxo;
- or a pharmaceutically acceptable salt or a solvate thereof;
- wherein the compound is not
A compound having the structure
- or a pharmaceutically acceptable salt or solvate thereof.
A compound having the structure
- or a pharmaceutically acceptable salt or solvate thereof.
A compound having the structure
- or a pharmaceutically acceptable salt or solvate thereof.
A compound having the structure
- or a pharmaceutically acceptable salt or solvate thereof.
A compound having the structure
- or a pharmaceutically acceptable salt or solvate thereof.
A compound having the structure
- or a pharmaceutically acceptable salt or solvate thereof.
A compound having the structure
- or a pharmaceutically acceptable salt or solvate thereof.
Dependencies are inferred from the claim text.