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US 9,427,427 B2Granted
Pharmaceutical composition with improved bioavailability
AssigneeHoffmann-La Roche Inc.
InventorsSteve Lomuscio, Hua Ma, Michael Allen Matchett, Harpreet K. Sandhu, Navnit Hargovindas Shah, Yu-E Zhang
Life of this patent
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Abstract
The invention relates to solid dispersions of poorly water soluble compounds, in particular Compound A as disclosed herein, formed by solvent co-precipitation or spray drying, resulting in improved bioavailability, safety and tolerability of said compounds.
Claims21
A physically stable solid dispersion comprising compound (A):
- and a stabilizing polymer, wherein said stabilizing polymer is Poly(methacylic acid)-co-methyl methacrylate or Poly(vinylpyrrolidone-co-vinyl acetate)(6+4).
A physically stable solid dispersion, comprising compound (A):
- and a stabilizing polymer that is Poly(vinylpyrrolidone-co-vinyl acetate)(6+4), wherein the ratio of the amount by weight of Compound A in the solid dispersion to the amount by weight of the stabilizing polymer therein is between 5:95 to 70:30.
Dependencies are inferred from the claim text.