Fatty-acid based particles
AssigneeAtrium Medical Corporation
InventorsThomas M. Swanick, Joseph Ferraro, Lisa Rogers, Paul Martakos
Life of this patent
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Abstract
The present invention is directed toward fatty acid-based particles, and methods of making such particles. The particles can be associated with an additional, therapeutic agent. Also provided herein is a method of forming fatty acid particles, comprising associating a cross-linked, fatty acid-derived biomaterial with a cryogenic liquid; and fragmenting the bio material/cryogenic liquid composition, such that fatty acid particles are formed. The particles can be used for a variety of therapeutic applications.
Claims24
A method of forming therapeutic fatty acid particles, comprising:
- (a) curing a fish oil combined with a therapeutic agent to form a bioabsorbable material comprising fatty acids cross-linked directly to each other by bonds formed during the curing process, wherein the bioabsorbable material is hydrolyzable by tissue into non-inflammatory components;
- (b) associating the bioabsorbable material with a cryogenic liquid;
- and
- (c) fragmenting the material/cryogenic liquid composition, such that therapeutic fatty acid particles are formed.
A method of forming therapeutic fatty acid particles comprising:
- (a) curing a fish oil to form a bioabsorbable material comprising fatty acids cross-linked directly to each other by bonds formed during the curing process, wherein the bioabsorbable material is hydrolyzable by tissue into non-inflammatory components;
- (b) combining the material and a therapeutic agent to form a composition;
- (c) submerging, surrounding, or suspending the composition in a cryogenic liquid;
- and
- (d) fragmenting the composition to form therapeutic fatty acid particles comprising cross-linked fatty acids and the therapeutic agent.
A method of forming therapeutic fatty acid particles, comprising the steps of:
- curing a fish oil to form a bioabsorbable material comprising fatty acids cross-linked directly to each other, wherein the bioabsorbable material is hydrolyzable by tissue into non-inflammatory components;
- loading the material with a therapeutic agent before associating the material with a cryogenic liquid;
- and
- fragmenting the material/cryogenic liquid composition, such that therapeutic fatty acid particles are formed.
A method of forming therapeutic fatty acid particles pressed into a film or three dimensional article, the method comprising the steps of:
- curing a fish oil to form a bioabsorbable material comprising fatty acids cross-linked directly to each other, wherein the bioabsorbable material is hydrolyzable by tissue into non-inflammatory components;
- combining the material and a therapeutic agent to form a composition;
- submerging, surrounding, or suspending the composition in a cryogenic liquid;
- fragmenting the composition to form therapeutic fatty acid particles comprising cross-linked fatty acids and the therapeutic agent;
- and
- pressing the therapeutic fatty acid particles into the film or three dimensional article.
Dependencies are inferred from the claim text.