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US 9,427,415 B2Granted
Methods and compositions for modifying sensorial perception
AssigneeThe Procter & Gamble Company
InventorsKoti Tatachar Sreekrishna, Yakang Lin
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Abstract
Compounds and methods for modifying sensory perception associated with transient sensory receptors TRPA1, TRPV1, and TRPA1V1. A method for screening compounds for modulation of TRPA1, TRPV1, and/or TRPA1V1. Compositions comprising TRPA1V1 agonists or antagonists, for modifying sensory perception of the compositions.
Claims1
A method of altering the sensory perception of burning, irritation, or pain from exposure to an oral care composition, the method comprising:
- incorporating a compound that modulates TRPA1V1 activity into an oral care composition;
- wherein the compound is trans,trans-2,4-undecadien-1-al;
- wherein the compound is present in an amount effective to reduce the activation of TRPA1V1 relative to the activation of at least one of TRPA1 or TRPV1.
Dependencies are inferred from the claim text.