Silica-matrix forming compositions, materials formed therefrom, and methods of using the same
AssigneesLisa Kasinkas, Eduardo Reategui, Alptekin Aksan
InventorsEduardo Reategui, Lisa Kasinkas, Alptekin Aksan
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Abstract
The present invention provides compositions for encapsulation of biomaterials in a silica-matrix. The present invention also provides methods of making silica-matrix encapsulated biomaterials, and to methods of using silica-matrix encapsulated biomaterials. In one embodiment, the present invention provides a method of encapsulating mammalian cells in a silica-matrix while maintaining metabolic activity. In another embodiment, the present invention provides a method of purifying cancer cells using a silica-matrix.
Claims14
A method of selectively purifying cancerous cells, comprising:
- obtaining or providing a mixture comprising:
- a reactive silicon compound;
- and,
- a biomaterial comprising at least one first living cancerous mammalian cell and at least one second living cancerous mammalian cell, the second living cancerous mammalian cell having a metabolic activity, the first living cancerous mammalian cell and the second living cancerous mammalian cell having different phenotypes;
- forming a reaction product of the mixture comprising a silica-matrix encapsulated biomaterial, wherein the second cancerous mammalian cell at least partially retains metabolic activity within the silica-matrix such that the first living cancerous mammalian cell dies at a faster rate than the second living cancerous mammalian cell;
- and
- removing the second cancerous mammalian cell from the silica-matrix after a period of time in which the second cancerous mammalian cell remains living after the first cancerous cell dies.
Dependencies are inferred from the claim text.