Preparation for improving solubility of poorly soluble drug

A solid preparation comprising:

• (A) a granulated substance comprising
• (i) a poorly soluble drug having a carboxyl group in the molecule,
• wherein the poorly soluble drug is an optically active compound represented by Formula (I):
• wherein,
• R1 is chosen from halogen atoms and C1-C3 alkyloxy groups;
• R2 is chosen from C1-C8 alkyl groups;
• R3 is chosen from C1-C8 alkyl groups;
• R4 and R5 are each independently chosen from a fluorine atom and a chlorine atom;
• R6 is chosen from C1-C3 alkyl groups and C1-C3 alkyl oxy groups;
• and
• the carbon atom with “*” attached to it is an asymmetric carbon, its pharmaceutically acceptable salt, or solvate thereof
• (ii) an alkaline agent,
• wherein the alkaline agent is chosen from magnesium oxide, magnesium hydroxide, hydroxylation alumina magnesium, synthetic hydrotalcite, calcium silicate and mixtures thereof,
• wherein the alkaline agent is present in an amount of 0.5 to 30 weight % based on the weight of the granulated substance,
• (iii) a surfactant,
• wherein the surfactant is chosen from sodium lauryl sulfate, sucrose fatty acid ester and polyoxyethylene polyoxypropylene glycol,
• wherein the surfactant is present in an amount of 0.2 to 50 weight % based on the weight of the granulated substance,
• wherein the granulated substance does not substantially contain a disintegrator, and
• (B) a disintegrator external to the granulated substance.