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US 9,427,012 B2Granted
Process of manufacturing a stable softgel capsule containing microencapsulated probiotic bacteria
AssigneeR.P. Scherer Technologies, LLC
InventorsClaudia Valla, Rosa Bertolami, Giovanni Rosina, Karen Helson
Life of this patent
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Abstract
A softgel capsule containing microencapsulated probiotic bacteria is manufactured such that the softgel capsule is stable for at least about 24 months at room temperature.
Claims20
A process of manufacturing a softgel capsule containing microencapsulated probiotic bacteria comprising the steps of:
- (a) providing microencapsulated probiotic bacteria with at least one coating comprising at least one vegetable lipid having a melting point of between about 35° C. and about 75° C.;
- (b) suspending the microencapsulated probiotic bacteria in a suspending formulation to make a fill;
- (c) mixing the fill at an intensity less than 3000 rpm and a temperature below 33° C. to make a mixed fill;
- (d) reducing agglomerates of the microencapsulated probiotic bacteria in the mixed fill to make a de-agglomerated fill;
- and
- (e) encapsulating the de-agglomerated fill in a softgel capsule,
- wherein the integrity of the coating of the microencapsulated probiotic bacteria is maintained.
4 more elements
A process of manufacturing a softgel capsule containing microencapsulated probiotic bacteria comprising the steps of:
- (a) providing microencapsulated probiotic bacteria with at least one coating comprising at least one vegetable lipid having a melting point of between about 35° C. and about 75° C.;
- (b) suspending the microencapsulated probiotic bacteria in a suspending formulation to make a fill;
- (c) mixing the fill at an intensity less than 3000 rpm and a temperature below 33° C. to make a mixed fill;
- (d) reducing agglomerates of the microencapsulated probiotic bacteria in the mixed fill to make a de-agglomerated fill;
- and
- (e) encapsulating the de-agglomerated fill in a softgel capsule,
- wherein the integrity of the coating of the microencapsulated probiotic bacteria is maintained, and
- wherein the softgel capsule is stable for at least about 18 months at room temperature.
5 more elements
Dependencies are inferred from the claim text.