Methods and compositions for neuroprotection
AssigneeQuark Pharmaceuticals, Inc.
InventorElena Feinstein
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Abstract
Disclosed herein are methods and kits useful for providing neuroprotection to neurons in the inner ear and to methods of treating inner ear diseases and disorders, including tinnitus and Mnire's disease.
Claims14
A method of treating Ménière's disease in a subject in need thereof, the method comprising administering to the subject's ear a double-stranded RNA (dsRNA) compound that down-regulates expression of a Caspase 2, Apoptosis-Related Cysteine Peptidase (CASP2) gene, wherein the CASP2 gene encodes an mRNA having a sequence set forth in any one of SEQ ID NO:1-3, in an amount effective to provide neuroprotection to a neuron in a spiral ganglion or a vestibular ganglion in the subject's ear.
Dependencies are inferred from the claim text.