Lipopolysaccharide-targeted peptide mimic vaccine against Q fever
AssigneeThe Curators of the University of Missouri
InventorGuoquan Zhang
Life of this patent
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Abstract
A vaccine and method of vaccination for conferring immunity to Q fever is described. The vaccine comprises a polypeptide with a sequence of SLTWHKHELHRK (SEQ ID NO: 7) (m1E41920) or SPPWHKHELHRK (SEQ ID NO: 8) (m1E44), or at least 90% identity to m1E41920 or m1E44. Constructs are also provided for use in vaccination and treatment of Q fever. A method to identify and generate new vaccines to prevent diseases caused by intracellular Gram-negative bacteria is also described.
Claims7
A lipopolysaccharide-based peptide mimetic for protection against infection of gram negative intracellular bacteria in a subject;
- wherein the lipopolysaccharide-based peptide mimetic sequence comprises a sequence of SLTWHKHELHRK (SEQ ID NO:
- 7) or SPPWHKHELHRK (SEQ ID NO:
- 8), or a peptide sequence having at least 90% identity to SLTWHKHELHRK (SEQ ID NO:
- 7) or SPPWHKHELHRK (SEQ ID NO:
- 8), or a pharmaceutically acceptable salt thereof.
A lipopolysaccharide-based peptide mimetic for protection against infection of gram negative intracellular bacteria in a subject, wherein the lipopolysaccharide-based peptide mimetic sequence comprises an amino acid sequence selected from the group consisting of:
- 1) SWFHPQRRHSHQ,
- (SEQ ID NO:
- 9)
- 2) SWMPHPRWSPQH,
- (SEQ ID NO:
- 10)
- 3) MHRAPSTHKLLP,
- (SEQ ID NO:
- 11)
- 4) ASWHQHYMKHKP,
- (SEQ ID NO:
- 12)
- 5) SEFHRHGDKEHK,
- (SEQ ID NO:
- 13)
- 6) CEFPRSWDMETN,
- (SEQ ID NO:
- 14)
- 7) SLTRHKPEPHRK,
- (SEQ ID NO:
- 15)
- 8) GGWHKHISRSDP,
- (SEQ ID NO:
- 16)
- 9) YHKHPHTYHNFK,
- (SEQ ID NO:
- 17)
- 10) HPKHPHTHTNDQ,
- (SEQ ID NO:
- 18)
- 11) HMHMHQHVAQTQ,
- (SEQ ID NO:
- 19)
- 12) HMGMTKINYSAL,
- (SEQ ID NO:
- 20)
- 13) SNYSDVKRLPTV,
- (SEQ ID NO:
- 21)
- and
- 14) SVNWQKQTISNL,
- (SEQ ID NO:
- 22)
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.