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US 9,422,541 B2Granted
Apparatus for the extracorporeal treatment of blood
AssigneeUniversity of Limerick
InventorsJakki Cooney, Todd Fumio Kagawa, Edmond Magner
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AssigneeUniversity of Limerick
InventorsJakki Cooney, Todd Fumio Kagawa, Edmond Magner
Estimating the term…
An apparatus for the extracorporeal treatment of blood comprising an extracorporeal blood circuit (2), a pump (6) configured to provide fluid displacement within the extracorporeal blood circuit, and a reaction chamber (8) connected to the extracorporeal blood circuit and configured to receive blood or plasma from the circuit and treat the blood or plasma. The reaction chamber comprises an protease enzyme immobilized to a support, in which the protease enzyme is specific for, and capable of irreversibly cleaving, a human C5a present in the blood or plasma, wherein the abundance of the human C5a in the treated blood or plasma is less than that in the untreated blood or plasma. The apparatus finds utility in the extracorporeal treatment of blood from patients with inflammatory conditions, especially auto-immune disease and sepsis.
An apparatus for the extracorporeal treatment of blood comprising:
An apparatus for treating human blood or a C5a-containing blood fraction, the apparatus comprising a protease enzyme irreversibly bound to a support, in which the protease enzyme is specific for, and capable of irreversibly cleaving, human C5a present in the blood or blood fraction such that the chemoattractant capability of the cleaved human C5a is reduced, wherein the protease enzyme is a recombinant bacterial C5a protease selected from the group consisting of SEQ ID NO:
A protease enzyme comprising the sequence of A-B-C-D, in which A is selected from the group consisting of SEQ ID NO:
Dependencies are inferred from the claim text.