Isolated B7-H4 specific compositions and methods of use thereof
AssigneeThe Trustees of the University of Pennsylvania
InventorsNathalie Scholler, Denarda Dangaj, Aizhi Zhao, Daniel J. Powell
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Abstract
The present invention relates to B7-H4-specific chimeric antigen receptor compositions and methods of use thereof.
Claims12
An isolated nucleic acid sequence encoding a chimeric antigen receptor (CAR), wherein the CAR comprises a human anti-B7-H4 antibody or antigen binding fragment thereof and a CD3 zeta signaling domain, and wherein the human anti-B7-H4 antibody or antigen binding fragment thereof comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1-4.
An isolated chimeric antigen receptor (CAR) comprising a human anti-B7-H4 antibody or antigen binding fragment thereof and a CD3 zeta signaling domain, wherein the human anti-B7-H4 antibody or antigen binding fragment thereof comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1-4.
A method of providing an anti-tumor immunity in a mammal, the method comprising administering to the mammal an effective amount of a genetically modified cell comprising an isolated nucleic acid sequence encoding a chimeric antigen receptor (CAR), wherein the CAR comprises a human anti-B7-H4 antibody or antigen binding fragment thereof and a CD3 zeta signaling domain, and wherein the human anti-B7-H4 antibody or antigen binding fragment thereof comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1-4.
A method of treating a mammal having a cancer, the method comprising administering to the mammal an effective amount of a genetically modified cell comprising an isolated nucleic acid sequence encoding a chimeric antigen receptor (CAR), wherein the CAR comprises a human anti-B7-H4 antibody or antigen binding fragment thereof and a CD3 zeta signaling domain, and wherein the human anti-B7-H4 antibody or antigen binding fragment thereof comprises an amino acid sequence selected from the group consisting of SEQ ID NOs:
- 1-4.
Dependencies are inferred from the claim text.