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US 9,422,328 B2Granted
Acoustic bioreactor processes
AssigneeFloDesign Sonics, Inc.
InventorsThomas J. Kennedy, III, Bart Lipkens, Louis Masi, Stanley Kowalski, III, Chris Leidel
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Abstract
A series of multi-dimensional acoustic standing waves is set up inside a growth volume of a bioreactor. The acoustic standing waves are used to hold a cell culture in place as a nutrient fluid stream flows through the cell culture. Biomolecules produced by the cell culture are collected by the nutrient fluid stream and separated downstream of the cell culture.
Claims20
A process for collecting biomolecules from a cell culture, comprising:
- suspending the cell culture in a growth volume of a bioreactor, the bioreactor including at least one ultrasonic transducer and a reflector located opposite the at least one ultrasonic transducer, each ultrasonic transducer being driven to produce a multi-dimensional acoustic standing wave that holds the cell culture in the growth volume;
- and
- flowing a nutrient fluid stream through the cell culture to collect the biomolecules.
Dependencies are inferred from the claim text.