Biomolecule labeling reaction container, and reactor and reaction method using the same

A reactor to label a first chemical compound that is a biomolecule with a second chemical compound that is a radioactivity labeling agent in a reaction container, having:

• a reaction container unit including a reaction container, wherein a flow channel is formed on a top face of a reaction container main body;
• a radioactivity labeling agent solidification section to remove a solvent in the solution of the second chemical compound and solidify the second chemical compound is formed at an intermediate section of the flow channel;
• a supply section of a solution of the first chemical compound, a solution induction flow channel section and a supply section of a solution of the second chemical compound are formed in order on the upstream side of the radioactivity labeling agent solidification section;
• a discharge section of the labeled solution is formed on the downstream side of the radioactivity labeling agent solidification section;
• and a radiation sensor is positioned to detect radiation of the radioactivity labeling agent solidification section;
• a liquid sending unit to supply the solution of the first chemical compound and the solution of the second chemical compound to the reaction container respectively and reciprocally send the solution of the first chemical compound to an upper part of the second chemical compound solidified at the radioactivity labeling agent solidification section;
• a recovery unit to recover a labeled solution in the reaction container;
• a radiation detection unit to measure a radiation quantity on the basis of a detection signal of the radiation sensor;
• and
• a control unit to control the reaction container unit, the liquid sending unit, the recovery unit, and the radiation detection unit;
• wherein the control unit stops reciprocal liquid sending by the liquid sending unit on the basis of the radiation quantity of the radiation detection unit.

A reaction method of labeling a first chemical compound that is a biomolecule with a second chemical compound that is a radioactivity labeling agent by using a reaction container, wherein a flow channel is formed on a top face of a reaction container main body, a radioactivity labeling agent solidification section is formed at an intermediate section of the flow channel, a supply section of a solution of the first chemical compound, a solution induction flow channel section and a supply section of a solution of the second chemical compound are formed in order on the upstream side of the radioactivity labeling agent solidification section, a discharge section of the labeled solution is formed on the downstream side of the radioactivity labeling agent solidification section, and a radiation sensor is positioned to detect radiation of the radioactivity labeling agent solidification section, the method comprising the processes of:

• introducing the solution of the second chemical compound that is the radioactivity labeling agent from a supply section of the second chemical compound into the radioactivity labeling agent solidification section, removing a solvent, and solidifying the second chemical compound;
• introducing a solution of the first chemical compound that is the biomolecule from a supply section of the first chemical compound;
• allowing a solution of the first chemical compound to pass reciprocally through an upper part of the solidified second chemical compound and labeling the first chemical compound with the second chemical compound;
• detecting radiation of the solidified second chemical compound;
• and
• stopping reciprocal liquid sending when a detected radiation quantity reaches a preliminary set numerical value and recovering the labeled solution.