Clickable polyoxetane carrier for drug delivery

A polymer, comprising a subunit having the formula:

• wherein:
• A is independently hydrogen, C1-10 alkyl, C3-10 alkenyl, C3-10 alkynyl, C3-20 cycloalkyl, C5-20 cycloalkenyl, C5-25 aryl, —OR1, —COOR1, —C(O)R1, —C(O)-halogen, —SR1, —OSO2R1, —CONR1R2, —NR1R2, —N3, or halogen;
• B is independently C1-10 alkylene, C3-10 alkenylene, C3-10 alkynylene, C3-20 cycloalkylene, C5-20 cycloalkenylene, C5-25 arylene, —COO—, —C(O)—, —S—, —CONR1—, —NR1—, —CH2CH2O—, —O—, or combination of two or more of the foregoing;
• C is independently C1-10 alkylene, C3-10 alkenylene, C3-10 alkynylene, C3-20 cycloalkylene, C5-20 cycloalkenylene, C5-25 arylene, —COO—, —C(O)—, —S—, —CONR1—, —NR1—, —CH2CH2O—, —O—, or combination of two or more of the foregoing;
• D is independently C1-10 alkylene, C3-10 alkenylene, C3-10 alkynylene, C3-20 cycloalkylene, C5-20 cycloalkenylene, C5-25 arylene, —COO—, —C(O)—, —S—, —CONR1—, —NR1—, —CH2CH2O—, —O—, or combination of two or more of the foregoing;
• X is A, pharmaceutically active agent, physiological targeting agent, diagnostic agent, peptide, protein, nucleic acid, imaging agent, or combination of two or more of the foregoing;
• a is 1;
• b is independently 0-10;
• c is independently 1-20;
• d is independently 0-20;
• q is greater than 0;
• R1 and R2 are independently hydrogen, C1-10 alkyl, C3-10 alkenyl, C3-10 alkynyl, C3-20 cycloalkyl, C5-20 cycloalkenyl, or C5-25 aryl;
• and wherein one or more of the alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, alkylene, alkenylene, alkynylene, cycloalkylene, cycloalkenylene, and arylene may independently be branched, unbranched, unsubstituted, substituted, or contain a hetero atom.

A polymer, comprising a subunit having the formula:

• wherein:
• C is independently C1-10 alkylene, C3-10 alkenylene, C3-10 alkynylene, C3-20 cycloalkylene, C5-20 cycloalkenylene, C5-25 arylene, —COO—, —C(O)—, —S—, —CONR1—, —NR1—, —CH2CH2O—, —O—, or combination of two or more of the foregoing;
• D is independently C1-10 alkylene, C3-10 alkenylene, C3-10 alkynylene, C3-20 cycloalkylene, C5-20 cycloalkenylene, C5-25 arylene, —COO—, —C(O)—, —S—, —CONR1—, —NR1—, —CH2CH2O—, —O—, or combination of two or more of the foregoing;
• c is independently 1-20;
• d is independently 0-20;
• p is greater than 0;
• R1 is independently hydrogen, C1-10 alkyl, C3-10 alkenyl, C3-10 alkynyl, C3-20 cycloalkyl, C5-20 cycloalkenyl, or C5-25 aryl;
• and wherein one or more of the alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, aryl, alkylene, alkenylene, alkynylene, cycloalkylene, cycloalkenylene, and arylene may independently be branched, unbranched, unsubstituted, substituted, or contain a hetero atom.