Methods and materials for reducing the severity of viral infections
AssigneeMayo Foundation for Medical Education and Research
InventorsMoses Rodriguez, Allan J. Bieber, Arthur E. Warrington, Jr., Meghan McGee Painter, Eric M. Poeschla
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Abstract
This document relates to methods and materials involved in treating and/or preventing and/or reducing the severity of a viral infection present in a mammal. For example, methods for increasing expression of an Oas gene family polypeptide, an Ifit gene family polypeptide, an Isg15 polypeptide, a Rig-1 polypeptide, a Mda5 polypeptide, and a Mx1 polypeptide in mammals using a lentiviral vector comprising nucleic acid encoding a picornavirus 3Dpol polypeptide (or a fragment thereof) are provided.
Claims7
A method for increasing expression of an Ifit1 polypeptide within a mammal, wherein said method comprises administering lentivirus particles comprising nucleic acid encoding a picornavirus 3Dpol polypeptide or a catalytically active fragment thereof to said mammal under conditions wherein expression of said Ifit1 polypeptide is increased, wherein said mammal is a mouse, dog, cat, cow, horse, or human.
Dependencies are inferred from the claim text.