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US 9,421,240 B2Granted
Compstatin analogs for treatment of neuropathic pain
AssigneeApellis Pharmaceuticals, Inc.
InventorsCedric Francois, Pascal Deschatelets
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Abstract
In some aspects, the present invention provides methods of treating a subject in need of treatment for neuropathic pain, the method comprising administering a compstatin analog to the subject. In some embodiments, the compstatin analog is administered parenterally, e.g., intravenously.
Claims9
A method of treating a subject in need of treatment for neuropathic pain, the method comprising:
- administering a therapeutically effective amount of a compstatin analog to the subject,
- wherein the compstatin analog is a compound that comprises a cyclic peptide having an amino acid sequence:
- Xaa1-Cys-Val-Xaa2-Gln-Asp-Xaa2*-Gly-Xaa3-His-Arg-Cys-Xaa4 (SEQ ID NO:
- 6);
- wherein:
- Xaa1 is Ile, Val, Leu, B1-Ile, B1-Val, B1-Leu or a dipeptide comprising Gly-Ile or B1-Gly-Ile, and B1 represents a first blocking moiety;
- Xaa2 is 1-methyltryptophan;
- Xaa2* is Trp or an analog of Trp;
- Xaa3 is His, Ala or an analog of Ala, Phe, Trp, or an analog of Trp;
- Xaa4 is L-Thr, D-Thr, Ile, Val, Gly, a dipeptide selected from Thr-Ala and Thr-Asn, or a tripeptide comprising Thr-Ala-Asn, wherein a carboxy terminal —OH of any of the L-Thr, D-Thr, Ile, Val, Gly, Ala, or Asn optionally is replaced by a second blocking moiety B2;
- and
- the two Cys residues are joined by a disulfide bond.
9 more elements
Dependencies are inferred from the claim text.