Lipidated glycoprotein particles and methods of use
AssigneeRamot at Tel-Aviv University Ltd.
InventorsRimona Margalit, Dan Peer
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Abstract
Lipidated micro- or macroparticles are prepared by covalently linking a glycoprotein, typically collagen, with at least one lipid. An amino group in the glycoprotein is joined with a primary amine in the lipid. These particles can be used to encapsulate active ingredients, such as drugs.
Claims9
A method for treating a patient suffering from osteoarthritis, comprising administering to the patient in need thereof an effective amount of a lipidated glycoprotein microparticle or macroparticle encapsulating diclofenac, wherein the lipidated glycoprotein microparticle or macroparticle has a solid porous interior and comprises the reaction product of at least one amino-containing glycoprotein covalently bound with at least one lipid having a primary amino group.
Dependencies are inferred from the claim text.