DNA vaccine for use in pancreatic cancer patients
AssigneeVaximm AG
InventorHeinz Lubenau
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Abstract
The present invention relates to an attenuated mutant strain of Salmonella comprising a recombinant DNA molecule encoding a VEGF receptor protein. In particular, the present invention relate to the use of said attenuated mutant strain of Salmonella in cancer immunotherapy.
Claims14
A method of treating pancreatic cancer comprising administering to a patient in need thereof a vaccine comprising an attenuated mutant strain of Salmonella typhi Ty21a comprising at least one copy of a recombinant DNA molecule comprising an expression cassette encoding a VEGF receptor protein having the amino acid sequence as found in SEQ ID NO 1, wherein the vaccine is administered in a single dose of 1×109 CFU or less than 1×109 CFU.
Dependencies are inferred from the claim text.