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US 9,415,077 B2Granted
Effect of an attenuated Bordetella strain against allergic disease
AssigneesInstitut National de la Sante et de la Recherche Medicale, Institut Pasteur de Lille, National University of Singapore
InventorsSylvie Claudette Alonso, Rui Li, Camille Locht
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Abstract
Described herein are compositions, vaccines, and methods that include use of a mutated Bordetella strain against allergic diseases such as asthma and skin inflammation. Also described are kits. Other compositions, vaccines, and methods are also described.
Claims8
A method of reducing a T-lymphocyte helper type 1 (Th1)-dominated allergic reaction in a mammal, comprising:
- colonizing the respiratory tract of the mammal by intranasally administering a live mutated Bordetella pertussis strain to the mammal, wherein the strain is mutated to reduce its production of functional pertussis toxin, dermonecrotic toxin, and tracheal cytotoxin while retaining the ability to colonize the mammal, wherein the colonization of the mammal elicits an anti-inflammatory response which reduces the Th1-dominated allergic reaction in the mammal.
Dependencies are inferred from the claim text.