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US 9,414,619 B2Granted
Liquid nutritional formula for phenylketonuria patients
AssigneeCambrooke Therapeutics, Inc.
InventorsCharles E. Sizer, Leah Alea, Kurt Olson
Life of this patent
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Abstract
This is a process to make a shelf-stable, liquid, ready-to-drink, aseptic nutritional formula for the treatment of PKU, tyrosinemia or other errors of metabolism. The liquid nutritional formula has caseino-glyco-macropeptide as the primary protein source and complementary essential amino acids to complete the requirement profile. The beverage also includes vitamins and minerals sufficient to meet daily requirements. When used as a complete diet, the nutritional formula includes a carbohydrate source and a fat source. The nutritional formula has a pleasant taste.
Claims11
A liquid nutritional formula suitable as a complete diet for phenylketonuria (PKU) comprising whey protein isolate, tyrosine, tryptophan, arginine, leucine, histidine, copper, iron, sodium hexametaphosphate (SHMP), and octenyl succinate starch (OSS), wherein the whey protein isolate consists of caseino-glycomacropeptide (cGMP).
A liquid nutritional formula comprising:
- Calories
- 200
- Cal From Fat
- 45
- Protein Equivalent, g
- 15
- Carbohydrates, g
- 24
- Sugar, g
- 19
- Sugar Alcohols, g
- 0
- Dietary Fiber, g
- 1
- Fat, g
- 5.0
- Saturated Fat, g
- 2.0
- Trans Fat, g
- 0.0
- Cholesterol, mg
- 0
- Vitamin A, IU
- 900.0
- Vitamin C, mg
- 28.0
- Vitamin D, IU
- 250.0
- Vitamin E, IU
- 5.0
- Vitamin K, mcg
- 30.0
- Thiamin (B1), mg
- 0.4
- Riboflavin (B2), mg
- 0.4
- Niacin (B3), mg
- 5.0
- Vitamin B6, mg
- 0.4
- Folic acid, mcg
- 140.0
- Vitamin B12, mcg
- 0.8
- Pantothenic Acid (B5), mg
- 1.8
- Biotin, mcg
- 8.0
- Choline, mg
- 206.0
- Calcium, mg
- 350.0
- Chromium, mcg
- 13.0
- Copper, mg
- 0.2
- Iodine, mcg
- 57.0
- Iron, mg
- 4.5
- Magnesium, mg
- 120.0
- Manganese, mg
- 0.8
- Molybdenum, mcg
- 15.0
- Phosphorus, mg
- 315.0
- Selenium, mcg
- 20.0
- Zinc, mg
- 3.3
- Potassium, mg
- 340
- Sodium, mg
- 240
- Chloride, mg
- 162.0
- Inositol, mg
- 0.0
- L-alanine, mg
- 560.0
- L-arginine, mg
- 1560.0
- L-aspartate, mg
- 800.0
- L-cysteine, mg
- 10.5
- L-glutamate, mg
- 2000.0
- L-glycine, mg
- 107.0
- L-histidine, mg
- 333.0
- L-isoleucine, mg
- 970.0
- L-leucine, mg
- 3000.0
- L-lysine, mg
- 650.0
- L-methionine, mg
- 152.0
- L-phenylalanine, mg
- 27.0
- L-proline, mg
- 1290.0
- L-serine, mg
- 560.0
- L-threonine, mg
- 1620.0
- L-tryptophan, mg
- 234.0
- L-tyrosine, mg
- 1150.0
- L-valine, mg
- 849.0,
- Calories
- 200
- Cal From Fat
- 45
- Protein Equivalent, g
- 15
- Carbohydrates, g
- 24
- Sugar, g
- 19
- Sugar Alcohols, g
- 0
- Dietary Fiber, g
- 1
- Fat, g
- 5.0
- Saturated Fat, g
- 2.0
- Trans Fat, g
- 0.0
- Cholesterol, mg
- 0
- Vitamin A, IU
- 900.0
- Vitamin C, mg
- 28.0
- Vitamin D, IU
- 250.0
- Vitamin E, IU
- 5.0
- Vitamin K, mcg
- 30.0
- Thiamin (B1), mg
- 0.4
- Riboflavin (B2), mg
- 0.4
- Niacin (B3), mg
- 5.0
- Vitamin B6, mg
- 0.4
- Folic acid, mcg
- 140.0
- Vitamin B12, mcg
- 0.8
- Pantothenic Acid (B5), mg
- 1.8
- Biotin, mcg
- 8.0
- Choline, mg
- 206.0
- Calcium, mg
- 350.0
- Chromium, mcg
- 13.0
- Copper, mg
- 0.2
- Iodine, mcg
- 57.0
- Iron, mg
- 4.5
- Magnesium, mg
- 120.0
- Manganese, mg
- 0.8
- Molybdenum, mcg
- 15.0
- Phosphorus, mg
- 315.0
- Selenium, mcg
- 20.0
- Zinc, mg
- 3.3
- Potassium, mg
- 340
- Sodium, mg
- 240
- Chloride, mg
- 162.0
- Inositol, mg
- 0.0
- L-alanine, mg
- 560.0
- L-arginine, mg
- 1560.0
- L-aspartate, mg
- 800.0
- L-cysteine, mg
- 10.5
- L-glutamate, mg
- 2000.0
- L-glycine, mg
- 107.0
- L-histidine, mg
- 333.0
- L-isoleucine, mg
- 970.0
- L-leucine, mg
- 3000.0
- L-lysine, mg
- 650.0
- L-methionine, mg
- 152.0
- L-phenylalanine, mg
- 27.0
- L-proline, mg
- 1290.0
- L-serine, mg
- 560.0
- L-threonine, mg
- 1620.0
- L-tryptophan, mg
- 234.0
- L-tyrosine, mg
- 1150.0
- L-valine, mg
- 849.0,
- Calories
- 153
- Cal From Fat
- 30
- Protein Equivalent, g
- 10
- Carbohydrates, g
- 22
- Sugar, g
- 17
- Sugar Alcohols, g
- 0
- Dietary Fiber, g
- 0
- Fat, g
- 3.5
- Saturated Fat, g
- 1
- Trans Fat, g
- 0.0
- Cholesterol, mg
- 0
- Vitamin A, IU
- 850.0
- Vitamin C, mg
- 20.0
- Vitamin D, IU
- 250.0
- Vitamin E, IU
- 5.0
- Vitamin K, mcg
- 30.0
- Thiamin (B1), mg
- 0.4
- Riboflavin (B2), mg
- 0.4
- Niacin (B3), mg
- 4.0
- Vitamin B6, mg
- 0.4
- Folic acid, mcg
- 133.0
- Vitamin B12, mcg
- 0.8
- Pantothenic Acid (B5), mg
- 1.8
- Biotin, mcg
- 8.0
- Choline, mg
- 203.0
- Calcium, mg
- 325.0
- Chromium, mcg
- 10.0
- Copper, mg
- 0.2
- Iodine, mcg
- 57.0
- Iron, mg
- 4.0
- Magnesium, mg
- 77.0
- Manganese, mg
- 0.8
- Molybdenum, mcg
- 14.0
- Phosphorus, mg
- 315.0
- Selenium, mcg
- 20.6
- Zinc, mg
- 3.3
- Potassium, mg
- 340
- Sodium, mg
- 250
- Chloride, mg
- 160.0
- Inositol, mg
- 0.0
- L-alanine, mg
- 369.0
- L-arginine, mg
- 1029.6
- L-aspartate, mg
- 567.0
- L-cysteine, mg
- 6.9
- L-glutamate, mg
- 1320.0
- L-glycine, mg
- 76.0
- L-histidine, mg
- 219.0
- L-isoleucine, mg
- 640.0
- L-leucine, mg
- 1980.0
- L-lysine, mg
- 429.0
- L-methionine, mg
- 100.0
- L-phenylalanine, mg
- 18.0
- L-proline, mg
- 851.0
- L-serine, mg
- 369.0
- L-threonine, mg
- 1069.0
- L-tryptophan, mg
- 154.0
- L-tyrosine, mg
- 759.0
- L-valine, mg
- 560.0,
- or
- Calories
- 153
- Cal From Fat
- 30
- Protein Equivalent, g
- 10
- Carbohydrates, g
- 22
- Sugar, g
- 17
- Sugar Alcohols, g
- 0
- Dietary Fiber, g
- 1
- Fat, g
- 3.5
- Saturated Fat, g
- 1
- Trans Fat, g
- 0.0
- Cholesterol, mg
- 0
- Vitamin A, IU
- 850.0
- Vitamin C, mg
- 20.0
- Vitamin D, IU
- 250.0
- Vitamin E, IU
- 5.0
- Vitamin K, mcg
- 30.0
- Thiamin (B1), mg
- 0.4
- Riboflavin (B2), mg
- 0.4
- Niacin (B3), mg
- 4.0
- Vitamin B6, mg
- 0.4
- Folic acid, mcg
- 133.0
- Vitamin B12, mcg
- 0.8
- Pantothenic Acid (B5), mg
- 1.8
- Biotin, mcg
- 8.0
- Choline, mg
- 203.0
- Calcium, mg
- 325.0
- Chromium, mcg
- 10.0
- Copper, mg
- 0.2
- Iodine, mcg
- 57.0
- Iron, mg
- 4.0
- Magnesium, mg
- 77.0
- Manganese, mg
- 0.8
- Molybdenum, mcg
- 14.0
- Phosphorus, mg
- 315.0
- Selenium, mcg
- 20.6
- Zinc, mg
- 3.3
- Potassium, mg
- 340
- Sodium, mg
- 250
- Chloride, mg
- 160.0
- Inositol, mg
- 0.0
- L-alanine, mg
- 369.0
- L-arginine, mg
- 1029.6
- L-aspartate, mg
- 567.0
- L-cysteine, mg
- 6.9
- L-glutamate, mg
- 1320.0
- L-glycine, mg
- 76.0
- L-histidine, mg
- 219.0
- L-isoleucine, mg
- 640.0
- L-leucine, mg
- 1980.0
- L-lysine, mg
- 429.0
- L-methionine, mg
- 100.0
- L-phenylalanine, mg
- 18.0
- L-proline, mg
- 851.0
- L-serine, mg
- 369.0
- L-threonine, mg
- 1069.0
- L-tryptophan, mg
- 154.0
- L-tyrosine, mg
- 759.0
- L-valine, mg
- 560.0
- per 250 mL of formula, wherein the Protein Equivalent comprises caseino-glycomacropeptide (cGMP), and wherein the formula comprises octenyl succinate starch (OSS) and sodium hexametaphosphate (SHMP).
463 more elements
A method of producing a nutritional formula suitable as a complete diet for phenylketonuria, the method comprising:
- (a) introducing, caseino-glycomacropeptide (cGMP), amino acids, vitamins and dry ingredients into a metered volume of water to produce a first mixture;
- (b) introducing sodium hexametaphosphate (SHMP) and sensitive minerals into a metered volume of water to produce a second mixture;
- (c) combining the first mixture and the second mixture;
- (d) combining an emulsion comprising tyrosine, octenyl succinate starch (OSS), sodium steroyl lactylate (SSL), cocoa butter, vegetable oil with the product of (c);
- and
- (e) adding Vitamin C to the product of (d), thereby producing a nutritional formula.
3 more elements
A liquid, nutritional formula suitable as a complete diet for phenylketonuria comprising:
- Calories
- 200.00
- Cal from Fat
- 45.00
- Protein Equivalent, g
- 15.00
- Carbohydrates, g
- 24.00
- Sugar, g
- 19.00
- Sugar alcohols, g
- 0.00
- Dietary Fiber, g
- 1.00
- Fat, g
- 5.00
- Saturated Fat, g
- 2.00
- Trans Fat, g
- 0.00
- Cholesterol, mg
- 0.00
- Vitamin A, mg
- 900.00
- Vitamin C, mg
- 28.00
- Vitamin D, IU
- 250.00
- Vitamin E, IU
- 5.00
- Vitamin K, mcg
- 30.00
- Thiamin (b1), mg
- 0.40
- Riboflavin (B2), mg
- 0.40
- Niacin (B3), mg
- 5.00
- Vitamin B6, mg
- 0.40
- Folic Acid, mcg
- 140.00
- Vitamin B12, mcg
- 0.80
- Pantothenic Acid (B5),
- 1.80
- mg
- Biotin, mcg
- 8.00
- Choline, mg
- 206.00
- Calcium, mg
- 350.00
- Chromium, mcg
- 13.00
- Copper, mg
- 0.20
- Iodine, mcg
- 57.00
- Iron, mg
- 4.50
- Magnesium, mg
- 120.00
- Manganese, mg
- 0.80
- Molybdenum, mcg
- 15.00
- Phosphorus, mg
- 315.00
- Selenium, mcg
- 20.00
- Zinc, mg
- 3.30
- Potassium, mg
- 340.00
- Sodium, mg
- 240.00
- Chloride, mg
- 162.00
- Inositol, mg
- 0.00
- L-alanine, mg
- 560.00
- L-arginine, mg
- 1560.00
- L-aspartate, mg
- 800.00
- L-cysteine, mg
- 10.50
- L-glutamate, mg
- 2000.00
- L-glycine, mg
- 107.00
- L-histidine, mg
- 333.00
- L-isoleucine, mg
- 970.00
- L-leucine, mg
- 3000.00
- L-lysine, mg
- 650.00
- L-methionine, mg
- 152.00
- L-phenylalanine, mg
- 27.00
- L-proline, mg
- 1290.00
- L-serine, mg
- 560.00
- L-threonine, mg
- 1620.00
- L-tryptophan, mg
- 234.00
- L-tyrosine, mg
- 1150.00
- L-valine, mg
- 849.00
- per 250 mL of formula, wherein the Protein Equivalent comprises caseino-glycomacropeptide (cGMP), and wherein the formula comprises octenyl succinate starch (OSS) and sodium hexametaphosphate (SHMP).
115 more elements
A liquid, nutritional formula suitable as a complete diet for phenylketonuria comprising:
- Calories
- 153.00
- Cal from Fat
- 30.00
- Protein Equivalent, g
- 10.00
- Carbohydrates, g
- 22.00
- Sugar, g
- 17.00
- Sugar alcohols, g
- 0.00
- Dietary Fiber, g
- 1.00
- Fat, g
- 3.50
- Saturated Fat, g
- 1.00
- Trans Fat, g
- 0.00
- Cholesterol, mg
- 0.00
- Vitamin A, mg
- 850.00
- Vitamin C, mg
- 20.00
- Vitamin D, IU
- 250.00
- Vitamin E, IU
- 5.00
- Vitamin K, mcg
- 30.00
- Thiamin (b1), mg
- 0.40
- Riboflavin (B2), mg
- 0.40
- Niacin (B3), mg
- 4.00
- Vitamin B6, mg
- 0.40
- Folic Acid, mcg
- 133.00
- Vitamin B12, mcg
- 0.80
- Pantothenic Acid (B5),
- 1.80
- mg
- Biotin, mcg
- 8.00
- Choline, mg
- 203.00
- Calcium, mg
- 325.00
- Chromium, mcg
- 10.00
- Copper, mg
- 0.20
- Iodine, mcg
- 57.00
- Iron, mg
- 4.00
- Magnesium, mg
- 77.00
- Manganese, mg
- 0.80
- Molybdenum, mcg
- 14.00
- Phosphorus, mg
- 315.00
- Selenium, mcg
- 20.60
- Zinc, mg
- 3.30
- Potassium, mg
- 340.00
- Sodium, mg
- 250.00
- Chloride, mg
- 160.00
- Inositol, mg
- 0.00
- L-alanine, mg
- 369.00
- L-arginine, mg
- 1029.60
- L-aspartate, mg
- 567.00
- L-cysteine, mg
- 6.90
- L-glutamate, mg
- 1320.00
- L-glycine, mg
- 76.00
- L-histidine, mg
- 219.00
- L-isoleucine, mg
- 640.00
- L-leucine, mg
- 1980.00
- L-lysine, mg
- 429.00
- L-methionine, mg
- 100.00
- L-phenylalanine, mg
- 18.00
- L-proline, mg
- 851.00
- L-serine, mg
- 369.00
- L-threonine, mg
- 1069.00
- L-tryptophan, mg
- 154.00
- L-tyrosine, mg
- 759.00
- L-valine, mg
- 560.00
- per 250 mL of formula, wherein the Protein Equivalent comprises caseino-glycomacropeptide (cGMP), and wherein the formula comprises octenyl succinate starch (OSS) and sodium hexametaphosphate (SHMP).
115 more elements
Dependencies are inferred from the claim text.