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US 9,410,971 B2Granted
Devices, systems and methods for evaluation of hemostasis
AssigneeHemoSonics LLC
InventorsFrancesco Viola, William F. Walker, Gregory V. Browne, Robert S. Magyar, Bjarne Hansen, Christopher G. Denny
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Abstract
Provided are devices, systems and methods for evaluation of hemostasis. Also provided are sound focusing assemblies.
Claims20
A device for evaluation of hemostasis, comprising:
- a plurality of test chambers each configured to receive blood of a test sample, each test chamber comprising a reagent or combination of reagents, wherein each chamber is configured to be interrogated to determine a hemostatic parameter of the blood received therein;
- a first chamber of the plurality comprising a first reagent or a first combination of reagents that interact with the blood received therein, wherein the first reagent, or a reagent included in the first combination of reagents, is an activator of coagulation;
- a second chamber of the plurality comprising a second combination of reagents that interact with blood of the test sample received therein, the second combination including an activator of coagulation and one or both of abciximab and cytochalasin D;
- and
- an interrogation device that measures at least one viscoelastic property of the test sample.
2 more elements
A system for evaluation of hemostasis comprising:
- a plurality of test chambers each configured to receive blood of a test sample, each test chamber comprising a reagent or combination of reagents;
- wherein a first chamber of the plurality comprises an activator of coagulation that interact with the blood received therein;
- wherein a second chamber of the plurality comprises an activator of coagulation and one or both of abciximab and cytochalasin D that interact with blood of the test sample received therein the combination including an activator of coagulation and;
- wherein the first chamber is configured to be interrogated with ultrasound for a hemostatic parameter of the blood received therein to be determined;
- wherein the second chamber is configured to be interrogated with ultrasound for a hemostatic parameter of the blood received therein to be determined;
- a transducer for transmitting ultrasound into one or more test chamber and for receiving reflected ultrasound from the chamber and the sample therein;
- and
- at least one processor in communication with the transducer, the processor being configured to determine the hemostatic parameters from signals transmitted to the processor from the transducer.
5 more elements
Dependencies are inferred from the claim text.