Recombinant microorganisms and uses therefor
AssigneeLanzatech New Zealand Limited
InventorsMichael Koepke, Sean Simpson, FungMin Liew, Wendy Chen
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Abstract
The invention provides, inter alia, methods for the production of acetone, isopropanol and/or precursors of acetone and/or isopropanol by microbial fermentation of substrates comprising CO, genetically modified microorganisms of use in such methods, nucleic acids suitable for preparation of genetically modified microorganisms, a novel alcohol dehydrogenase and nucleic acids encoding same.
Claims21
A recombinant microorganism comprising an exogenous thiolase (EC 2.3.1.9), an exogenous CoA transferase (EC 2.8.3.9), and an exogenous decarboxylase (EC 4.1.1.4 or EC 4.1.1.74), wherein the recombinant microorganism is derived from a parental microorganism selected from the group consisting of Clostridium autoethanogenum, Clostridium ljungdahlii, and Clostridium ragsdalei, wherein the recombinant microorganism produces isopropanol.
Dependencies are inferred from the claim text.